Action of Artemisia annua on adaptive immunity in COVID-19 infections

Concept notes n° 1

Final revised version of the concept note written by Dr. Catherine Poisson-Benatouil, Anesthesist-Reanimator "Action of Artemisia annua on adaptive immunity in COVID infections19". This text is the first in a series of articles discussing the potential of Artemisia annua to counteract the deleterious action of Covid19.

Artemisia and Coronavirus II

Action of Artemisia annua on adaptive immunity in COVID-19 infections

Concept notes n° 1


Antiviral herbal medicines have already been used in many epidemics, notably in the two previous coronavirus outbreaks - MERS-CoV in 2012, SARS-CoV in 2013 - or in seasonal epidemics caused by influenza or dengue viruses.

In coronavirus infection (COVID-19), cellular adaptive immunity is primarily involved, in particular CD8 and CD4 lymphocytes that stimulate the B lymphocytes responsible for the production of antibodies targeting the coronavirus. In addition, there is a cytokine storm in patients infected with COVID-19 responsible for a major inflammatory response and their very severe progressive clinical state. The increase in interleukin-10 and TNF alpha reduces CD4 counts, causes functional exhaustion of immune cells and induces, at their site of action (liver, vascular endothelium), runaway production and action of inflammation proteins, causing the secondary aggravation of COVID-19 patients.

Artemisia annua has a recognized antiviral activity (anti HSV1, Poliovirus, RSV, hepatitis C anti-virus, type 2 dengue virus, hantavirus, human cytomegalovirus) and antiHIV in vitro thanks to the flavonoids, quercetin and dicaffeoylquinic acids it contains. These molecules have been shown to inhibit the enzymaticactivity of CLPro (Chymotrypsin-like protease), an enzyme produced by SARS-CoV-2.

The antiviral action of Artemisia annua, which is achieved by stimulating adaptive immunity, regulating the production of the pro-inflammatory cytokines prostaglandin E2 (PGE2), IL-6, IL-10, TNF alpha and increasing the genesis of CD4, CD8 and interferon gamma, involves many minerals and biomolecules: the properties of flavonoids, polyphenols, triterpenes, sterols, saponins, polysaccharides, artemisinin and its derivatives, the concentration of zinc, gallium and selenium in the plant play a role in the immune, antiviral, antioxidant and anti-inflammatory response.

The plant is rich in Vitamins A and E, of which one, when supplemented, is known to reduce morbidity and mortality in viral infections, HIV among others, and the other is a powerful antioxidant.

It is therefore the combination of these biomolecules and the intake of Artemisia annua in totum that could improve exhausted adaptive immunity and modulate the runaway inflammatory response during COVID-19 infection, as this plant has already demonstrated in other serious viral and parasitic infections.

Dr Catherine Poisson-Benatouil
Maison de l’Artemisia de Pointe Noire | République du Congo




 Action de l’Artemisia annua sur l’immunité adaptative dans les infections COVID-19
 Maison de l’Artemisia | Inter-Culturel
 Action of Artemisia annua on adaptive immunity in COVID-19 infections
 Maison de l’Artemisia | Inter-Culturel

Concept notes on the antiviral, immomodulating and immunostimulant properties of {Artemisia annua} L.

This folder contains concept notes on the antiviral, immomodulating and immunostimulant properties of Artemisia annua L.

Articles 2

This concept note was written by Dr. Catherine Poisson-Benatouil, Anesthesiologist - Intensive Care Physician, and revised by the consultant Jean-Luc (...)
Note de synthèse rédigée par le Dr. Catherine Poisson-Benatouil, Anesthésiste-Réanimateur, et révisée par le consultant Jean-Luc (...)
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