Études in vivo des propriétés antischistosomiase (bilharziose)

Artemisia afra Jacq.

2018

Jérôme Munyangi, Lucile Cornet-Vernet, Michel Idumbo, Chen Lu, Pierre Lutgen, Christian Perronne, Nadège Ngombe, Jacques Bianga, Bavon Mupenda, Paula Lalukala, Guy Mergeai, Dieudonné Mumba, Melissa Towler, Pamela Weather
Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial
Phytomedicine 51 (2018) 233–240

Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial

Abstract :

Background and Objective : Schistosomiasis (bilharzia), a serious neglected tropical disease affecting millions, has few cost-effective treatments, so two Artemisia wormwood species, A. annua and A. afra, were compared with the current standard praziquantel (PZQ) treatment in an 800 patient clinical trial, August-November of 2015.

Methods : The double blind, randomized, superiority clinical trial had three treatment arms : 400 for PZQ, 200 for A. annua, and 200 for A. afra. PZQ-treated patients followed manufacturer posology. Artemisia-treated patients received 1l/d of dry leaf/twig tea infusions divided into 3 aliquots daily, for 7 days with 28-day follow-up.

Results : Of 800 enrolled patients having an average of >700 Schistosoma mansoni eggs per fecal sample, 780 completed the trial. Within 14 days of treatment, all Artemisia-treated patients had no detectable eggs in fecal smears, a result sustained 28 days post treatment. Eggs in fecal smears of PZQ-treated patients were undetectable after D21. More males than females who entered the trial had melena, but both genders responded equally well to treatment ; by D28 melena disappeared in all patients. In all arms, eosinophil levels declined by about 27% from D0 to D28. From D0 to D28 hemoglobin increases were greater in PZQ and A. afra-treated patients than in A. annua-treated patients. Hematocrit increases were greater from D0 to D28 for patients treated with either PZQ or A. annua compared to those treated with A. afra. Gender comparison showed that A. afra–treated males had significantly greater hemoglobin and hematocrit increases by D28 than either PZQ or A. annua–treated males. In contrast, PZQ and A. afra-treated females had greater hemoglobin and hematocrit increases than A. annua-treated females. Both adults and pediatric patients treated with A. annua responded better compared to PZQ treatment.

Conclusion : Both A. annua and A. afra provided faster effective treatment of schistosomiasis and should be considered for implementation on a global scale.

Keywords : Artemisinin, Artemisia, Bilharzia, Tea infusion, Wormwood

2019

Xavier Argemi, Jean Gaudart, André Gillibert, Eric Caumes, Stéphane Jauréguiberry, Nicolas Meyer
Comment on “Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial”
Phytomedicine Volume 62, September 2019, 152804
Correspondence

Comment on “Effect of {Artemisia annua} and Artemisia afra tea infusions on schistosomiasis in a large clinical trial”

***

Lucile Cornet-Vernet, Jerome Munyangi, Lu Chen, Melissa Towler, Pamela Weathers
Response to Argemi et al. 2019
Phytomedicine (2019)

Response to Argemi et al. 2019
Mis en ligne par La vie re-belle
 3/04/2020
 https://lavierebelle.org/artemisia-afra-etudes-in-vivo-des-184

 Documents

 Comment on “Effect of {Artemisia annua} and Artemisia afra tea infusions on schistosomiasis in a large clinical trial”
PDF 
 Phytomedicine
 Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial
PDF 
 Response to Argemi et al. 2019
PDF 
 Phytomedicine

Études in vivo

Études in vivo de la plante Artemisia afra

Les articles 4

IMG: Étude in vivo des propriétés antipaludiques Cet article recense et donne accès aux études in vivo des propriétés antipaludiques d’Artemisia afra
IMG: Études in vivo des propriétés antituberculeuses Cet article recense les publications concernant les études in vivo des propriétés antituberculeuses d’Artemisia afra Jacq.
Cet article regroupes les publications concernant les études in vivo des propriétés Cardiovasculaires d’Artemisia afra Jacq
IMG: Études in vivo des propriétés antidiabétiques Cet article regroupes les publications concernant les études in vivo des propriétés antidiabétiques d’Artemisia afra Jacq
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