Artemisia afra - In vivo studies of Cardiovascular effects

Artemisia afra Jacq.

Cet article regroupes les publications concernant les études in vivo des propriétés Cardiovasculaires d’Artemisia afra Jacq


A.N. Guantai & I. Addae-Mensah
Cardiovascular Effect of Artemisia afra and its Constituents
Pharmaceutical Biology, 37:5, 351-356, (1999)

Cardiovascular Effect of {Artemisia afra} and its Constituents


The cardiovascular effects of a mixture of long chain fatty esters (C 44 H 88 O 2 ) and scopoletin isolated from Atemisia afra and an aqueous extract of the plant were investigated in rabbits. The long chain fatty esters induced hypotensive effects at doses of 0.5, 1.0, 1.5 and 3 mg/kg. The diastolic pressure was affected more than the systolic. Aqueous A. afra extract (10–45 mg/kg) had a hypotensive effect in vivo and a dose-dependent biphasic effect on the heart in vitro. Lower doses induced an initial cardiostimulation followed by cardiodepression, whereas higher doses were mainly cardiodepressant. Scopoletin, a coumarin derivative, at a dose of 1.0–2.5 mg, induced a dose-dependent decrease in inotropic activity plus an appreciable decrease in chronotropic effects, especially at higher dose levels. These results suggest that A. afra and its constituents are potentially useful for the management of hypertensive conditions.


Charlotte M. Tata, Gwebu Ephraim Tobela, Olukayode Aremu, Constance Sewani-Rusike, Adebola Omowunmi Oyedeji, Oyedeji Opeopluwa Oyehan, Benedicta Nkeh-Chungag,
Acute Toxicity and Antihypertensive Effects of Artemisia afra and Leonotis leonurus in Spontaneously Hypertensive Rats
November 2018, Research Journal of Biotechnology 13(1):20-25


Acute toxicity and antihypertensive effects of hydroethanolic extracts of Artemisia afra and Leonotis leonurus were studied in Swiss albino mice and spontaneously hypertensive rats (SHR) respectively. Phytochemical screening was determined by colorimetric techniques. Lorke’s method for acute toxicity testing was carried out in two phases: in phase I three groups of mice (n = 3) were treated with 10, 100 or 1000 mg/kg of the extracts while in phase II mice were treated with 1600, 2900 or 5000 mg/kg of the extracts. Blood pressure, heart rate, blood flow and blood volume were measured using a non-invasive tail cuff method before treatment and 2, 4, 6, 8 and 24 hrs after treatment. Phytochemical screening revealed the presence of phenols, terpenoids, flavonoids, glycosides, tannins, steroids, triterpenoids and saponins. Both plant extracts were non-toxic with LD50 values greater than 5000 mg/kg. Artemesia afra extracts had its greatest (p<0.01) antihypertensive effects at 2 and 4 hrs post treatment while the effects of Leonotis leonurus were weak at best. The antihypertensive effects of A. affra and L. leonurus were significantly higher (p<0.01) than the effects of furosemide 24 hrs post treatment. Results from this study suggest that even though A. afra and L. leonurus are used for hypertension treatment in South African traditional medicine, the former displayed better antihypertensive effects compared to the latter in SHR.

Published online by La vie re-belle


 Cardiovascular Effect of {Artemisia afra} and its Constituents
 Pharmaceutical Biology
 2018-antihypertensive_effects_of_a_afra_and_l_leonurus_i (...)

In vivo studies

In vivo studies of Artemisia afra

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