Études in vivo des effets Cardiovasculaires

Artemisia afra Jacq.

Cet article regroupes les publications concernant les études in vivo des propriétés Cardiovasculaires d’Artemisia afra Jacq

1999

A.N. Guantai & I. Addae-Mensah
Cardiovascular Effect of Artemisia afra and its Constituents
Pharmaceutical Biology, 37:5, 351-356, (1999)

Cardiovascular Effect of {Artemisia afra} and its Constituents

Abstract :

The cardiovascular effects of a mixture of long chain fatty esters (C 44 H 88 O 2 ) and scopoletin isolated from Atemisia afra and an aqueous extract of the plant were investigated in rabbits. The long chain fatty esters induced hypotensive effects at doses of 0.5, 1.0, 1.5 and 3 mg/kg. The diastolic pressure was affected more than the systolic. Aqueous A. afra extract (10–45 mg/kg) had a hypotensive effect in vivo and a dose-dependent biphasic effect on the heart in vitro. Lower doses induced an initial cardiostimulation followed by cardiodepression, whereas higher doses were mainly cardiodepressant. Scopoletin, a coumarin derivative, at a dose of 1.0–2.5 mg, induced a dose-dependent decrease in inotropic activity plus an appreciable decrease in chronotropic effects, especially at higher dose levels. These results suggest that A. afra and its constituents are potentially useful for the management of hypertensive conditions.

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 3/04/2020
 https://lavierebelle.org/artemisia-afra-etudes-in-vivo-des-185

 Documents

 Cardiovascular Effect of {Artemisia afra} and its Constituents
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 Pharmaceutical Biology

Études in vivo

Études in vivo de la plante Artemisia afra

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